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Orsiro®Mission

Delivering superiority¹ᵃ

Orsiro Mission DES is indicated for improving coronary luminal diameter in patients with symptomatic ischemic heart disease due to discrete de-novo stenotic lesions and in-stent restenotic lesions (length ≤ 40 mm) in the native coronary arteries with a reference vessel diameter of 2.25 mm to 4.0 mm including the following patient and lesion subsets:

  • Acute Coronary Syndrome (ACS)
  • ST-Elevation Myocardial Infarction (STEMI)
  • Diabetes Mellitus (DM)
  • High Bleeding Risk (HBR)
  • One Month of Dual Antiplatelet Therapy (DAPT) in HBR Patients
  • Calcified Lesions (moderate/severe calcification)
  • Complex Lesions (B2/C)
  • Long Lesions (LL) (e.g. ≥ 20 mm)
  • Small Vessels (SV) (e.g. ≤ 2.75 mm)
  • Multi-Vessel Disease (MVD)
  • Male/Female
  • Old Patients (e.g. > 65 y)

Category

Vascular Intervention Coronary Drug-Eluting Stent System

Product Highlights

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The next level of deliverability²

1st in Push3, 1st in Track3, 1st in Cross3

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Ultrathin struts⁴

For early endothelialization5

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Outstanding patient outcomes⁶ᵇ

Proven superiority in STEMI up to 5 years1,b,c

The next level of deliverability²

Orsiro Mission DES transmits up to 96% more force from hub to tipd, requires 33% less force to follow the path to the lesiond, and 64% less force to crosse.

1st in Push³

Transmitting up to 96% more force from hub to tip.

1st in Track³

Up to 33% less force needed to follow the path to the lesion.

1st in Cross³

Up to 64% less force needed to successfully cross demanding anatomies.
 

Ultrathin struts4

For early endothelialization5 

Outstanding patient outcomes6,b

Orsiro DES proves continued superiority in the first randomized controlled trial demonstrating superiority between two contemporary DES12

Orsiro family of DES – One of the most studied DES14,b,i

Continued superiority in STEMI at 5 years15,b

In the BIOSTEMI trial, Orsiro DES is proven to be safe and effective at short- and long-term follow-up with 31% significantly less Target Lesion Failure (TLF) at 5-year in STEMI patients15,b

Product Overview

Orsiro Mission

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Technical Data

Stent  
Stent material Cobalt chromium, L-605
Strut thickness ø 2.25 – 3.0 mm: 60 µm (0.0024”);
ø 3.50 – 4.0 mm: 80 µm (0.0031”)
Passive coating proBIO® (Amorphous Silicon Carbide)
Active coating BIOlute® bioabsorbable Poly-L-Lactide (PLLA) eluting a limus drug
Drug dose 1.4 µg/mm²
Delivery system  
Catheter type Rapid exchange
Recommended guide catheter 5F (min. I.D. 0.056”)
Guide wire diameter 0.014”
Usable catheter length 140 cm
Balloon material Semi crystalline polymer material
Coating (Distal shaft) Hydrophilic
Coating (Proximal shaft) Hydrophobic
Marker bands Two swaged platinum-iridium markers
Lesion entry profile 0.017”
Distal shaft diameter 2.7F: ø 2.25 – 3.0 mm; 2.9F: ø 3.5 – 4.0 mm
Proximal shaft diameter 2.0F
Nominal pressure (NP) 10 atm
Rated burst pressure (RBP) 16 atm
Storage  
Use Before Date (UBD) 24 months
Temperature Between 15°C (59°F) and 25°C (77°F), short term excursions between 10°C (50°F) and 40°C (104°F) are allowed
Double Helix Stent Design             
Nominal diameter (mm) 2.25 2.5 2.75 3.0 3.5 4.0
Strut thickness (μm) 60 = = = 80 =
Strut width (μm) 75 = = = 85 =
Amount of connectors  3 = = = = =
Amount of crowns at end  8 = = = = =
Maximal Expansion and Stent Strut Opening            
Nominal diameter (mm) 2.25 2.5 2.75 3.0 3.5 4.0
Nominal outer diameter of the stent at NP (mm) 2.37 2.62 2.87 3.12 3.66 4.16
Maximal expansion diameter (mm) 4.0 = = = 5.0 =
Stent strut opening diameter at NP* (mm) 0.79 0.92 = = 1.06 1.25
Maximal diameter of expanded stent cell (mm) 3.59 = = = 4.42 =

*Mean of the largest possible opening diameter within a stent cell at NP 
= symbol used to show repetition 

Ordering Information

Stent

ø (mm)
Stent Length

(mm)
  9 13 15 18 22 26 30 35 40
2.25 419101 419107 419113 419119 419125 419131 419137 419143 419149
2.5 419102 419108 419114 419120 419126 419132 419138 419144 419150
2.75 419103 419109 419115 419121 419127 419133 419139 419145 419151
3.0 419104 419110 419116 419122 419128 419134 419140 419146 419152
3.5 419105 419111 419117 419123 419129 419135 419141 419147 419153
4.0 419106 419112 419118 419124 419130 419136 419142 419148 419154

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References

a. BIOTRONIK data on file (n = 5), based on statistically significant differences on the bench for Pushability, Trackability, and Crossability compared to Xience Skypoint, superior to Xience in STEMI patients; b. Clinical data collected with Orsiro DES device within the Orsiro DES family clinical program; c. In comparison to Xience, based on TLF with Orsiro DES; d. In comparison to Resolute Onyx, BIOTRONIK data on file; e. In comparison to Synergy XD, BIOTRONIK data on file; f. Always refer to the Instructions for Use (IFU) for the Maximum Diameter for post-dilation applying in your country; g. Ø 2.25-3.0 mm strut thickness 60 µm, Ø 3.5-4.0 mm strut thickness 80 µm; h. Images: Secco G et al. Time-related changes in neointimal tissue coverage following a new generation SES implantation: an OCT observational study. Presented at: euro PCR, May 20, 2014; Paris, France, i. Clinical data collected with Orsiro Mission DES device within the Orsiro DES family clinical program; j. At 5-year in STEMI patients. 


1. Iglesias JF. et al, Long-term outcomes with biodegradable polymer sirolimus eluting stents versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomized superiority trial, The Lancet, 2024; 2. In comparison to Xience Sierra, Resolute Onyx and Synergy for bench tests on pushability, trackability and crossability, BIOTRONIK data on file; 3. In comparison to Resolute Onyx, Xience Sierra and Synergy, BIOTRONIK data on file; 4. As characterized with respect to strut thickness in Bangalore et al. Meta-analysis; 5. Per investigators’ interpretation in Secco et al. Imaging data serial observations. Secco GG et al. Time-related changes in neointimal tissue coverage of a novel Sirolimus eluting stent: Serial observations with optical coherence tomography. Cardiovascular Revascularization Medicine. 2016; 17(1): 38-43; 6. Based on investigator’s interpretation of BIOFLOW-V endpoint results; 7. Based on Kapoor A. et al., The road to the ideal stent: A review of stent design optimization methods, findings, and opportunities, Materials&Design, 2024; 8. Stefanini GG et al. Coronary stents: novel developments. Heart. 2014 Jul 1;100(13):1051-61; 9. Low AF. Stent platform for procedural success: Introducing the Continuous Sinusoidal & Core Wire Technologies. Presented at: AsiaPCR; 22-24 January, 2015; Singapore, Singapore; 10. Tolentino A. Evolving DES Strategy: Biodegradable Polymer vs. Bioabsorbable Scaffold. Presented at: Cardiovascular Nurse/Technologist Symposium; June 17, 2016; New York, USA; 11. Secco G et al. Time-related changes in neointimal tissue coverage of a novel Sirolimus eluting stent: Serial observations with optical coherence tomography. Cardiovascular Revascularization Medicine 17.1 (2016): 38-43; 12. Pilgrim et al. Biodegradable – versus durable-polymer drug-eluting stents for STEMI. Final 2-year outcomes of the BIOSTEMI trial. J Am Coll Cardiol. Cardiovasc Interven. 2021, doi: 10.1016/j.jcin.2020.12.011; 13. BIOTRONIK data on file, status February 2023; 14. In large RCTs, based on Taglieri et al. Meta-analysis, against currently used DES; 15. Based on TLF primary endpoint. Iglesias, JF. et al. Long-term outcomes with biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomized superiority trial, presented at TCT 2023; 16. Kandzari D et al. Ultrathin Bioresorbable Polymer Sirolimus-Eluting Stents versus Thin Durable Polymer Everolimus-Eluting Stents for Coronary Revascularization: Final 5-year Outcomes from the Randomized BIOFLOW V Trial, Submitted manuscript to JACC, 2022: NCT02389946; 17. Valgimigli M et al. Circulation 2023 Aug 25, 18. Taglieri N et al. Target lesion failure with current drug-eluting stents evidence from a comprehensive network meta-analysis. JACC 2020.

Orsiro, Orsiro Mission, proBIO and BIOlute are trademarks or registered trademarks of the BIOTRONIK Group of Companies. All other trademarks are the property of their respective owners.